The opposites appeal to themselves. Milly (Collette) has all of it: a profitable profession, a loyal husband and two lovely youngsters. Her greatest buddy Jess (Barrymore), however, works in a neighborhood backyard, lives in a ship home along with her boyfriend and desperately needs to have a child. Mates since childhood, Jess and Mille have at all times shared secrets and techniques, garments, even boyfriends; Their variations are what retains them collectively. A accident will unite them much more, however as Jess tries to stability her life and nonetheless help Milly, the stress of this friendship begins to change into troublesome to bear.